Objectives: Mahwangkanghwal-tang(Mahuangqianghuo-tang;MKT) is a prescription that treat clinically arthritis. The purpose of this study is to investigate effects of MKT extract on the adjuvant arthritis in pathological rats induced by Freund’s complete adjvant(0.2 ㎖/㎏).
Methods: Experimental groups were divided into 4 groups ; Normal group were administered DDW 1.0 ㎖ to normal rats for 14 days, Control group were administered DDW 1.0 ㎖ to arthritic rats for 14 days, Sample A group were administered MKT 300 ㎎/㎏ 1.0 ㎖ to arthritic rats for 14 days, Sample B group were administered MKT 500 ㎎/㎏ 1.0 ㎖ to arthritic rats for 14 days. The present author observed body weight, inhibitory effect of edema, analgesic effects by hot plate, WBC, RBC, hemoglobin, hematocrit, platelet, total serum protein level and total serum cholesterol level.
Results:
1. All sample group were increased body weight compared with control group, sample B group were significantly increased body weight compared with control group.
2. All sample group significantly inhibited the rate of paw edema compared with control group.
3. All sample group significantly prolongated the escaping time compared with control group, sample B group significantly prolongated the paw licking time compared with control group.
4. All sample group were significantly decreased WBC compared with control group, sample B group were significantly decreased RBC compared with control group.
5. All sample group were decreased hemoglobin and hematocrit compared with control group.
6. All sample group were significantly decreased platelet compared with control group, sample B group were significantly decreased platelet compared with control group.
7. All sample group were significantly decreased total serum protein level compared with control group.
8. All sample group were increased total serum cholesterol compared with control group, sample B group were significantly increased total serum cholesterol level compared with control group.
Conclusions: We thought that Mahwangkanghwal-tang(Mahuangqianghuo-tang) could be used for curing rheumatoid arthritis, anti-inflammatory effect was somewhat better in much than small dosage.
|